As an effort to synthesize new heterocyclic compounds, which would expected to have pharmacological and biological activities. We report here the reactivity of 1H-indazole-5- carboxamide 2, as Michael acceptors under different conditions, towards different Michael donors namely, hydrazine hydrate, hydroxylamine hydrochloride and O-phenylene diamine forming adducts 4 – 8. Pyrazolopyrimidine derivative 9 used as precursor for preparation some fused heterocyclic compounds 10 – 12. The structures of the products obtained were confirmed by elemental analysis, IR, 1HNMR, 13C NMR and mass spectra. The biological activities for some synthesized products are screened.