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Utility of 4-arylidene-3-methyl-1H-pyrazole on Michael Addition reactions for biological evaluation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Utility of 4-arylidene-3-methyl-1H-pyrazole on Michael Addition reactions for biological evaluation

Author(s): Hayam H. Sayed*, Hebat-Allah S. Abbas**, Eman M. H. Morsi, Eman M. Flefel

As an effort to synthesize new heterocyclic compounds, which would expected to have pharmacological and biological activities. We report here the reactivity of 1H-indazole-5- carboxamide 2, as Michael acceptors under different conditions, towards different Michael donors namely, hydrazine hydrate, hydroxylamine hydrochloride and O-phenylene diamine forming adducts 4 – 8. Pyrazolopyrimidine derivative 9 used as precursor for preparation some fused heterocyclic compounds 10 – 12. The structures of the products obtained were confirmed by elemental analysis, IR, 1HNMR, 13C NMR and mass spectra. The biological activities for some synthesized products are screened.


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