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UV-Spectrophotometric determination of minoxidil and its application to the assay in pharmaceutical dosage forms | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

UV-Spectrophotometric determination of minoxidil and its application to the assay in pharmaceutical dosage forms

Author(s): Zahid A Zaheer, Shahed Mirza, Ismail Moazzam, Imran W Sayad

A selective and sensitive spectrophotometric method for determination of Minoxidil has been validated by three simple, precise and economical UV methods have been developed for the estimation of Minoxidil in Pharmaceutical solution. Minoxidil has the absorbance maxima at 285 nm (Method A), and in the first order derivative spectra, showed sharp peak at 267 nm (Method B). Method C applied was in the wavelength range of 280-288 nm. All the process was carried out in methanol as the solvent. Linearity for detector response was observed in the concentration range of 5-40μg/mL for Method A, Method B and Method C. The proposed methods were successfully applied for the determination of Minoxidil in there commercial preparation. The method allows rapid analysis of pharmaceutical formulation with accuracy and precise. Analysis was validated by statistically and recovery studies which was found satisfactory.


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