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Validated RP- HPLC and specrophotometric determination of Ropinirole hydrochloride in bulk and in pharmaceutical dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Validated RP- HPLC and specrophotometric determination of Ropinirole hydrochloride in bulk and in pharmaceutical dosage form

Author(s): Lata P. Kothapalli, Madhuri E. Choudhari, Asha B. Thomas, Rabindra K. Nanda, Avinash D. Deshpande, Punam S. Gaidhani

Ropinirole hydrochloride is a nonergot dopamine agonist, indicated for the treatment of the signs and symptoms of Parkinson's disease. The objective of this study is to develop validated HPLC (Method-I) and first order derivative spectrophotometric method (Method -II) for the estimation of ropinirole hydrochloride. A sharp peak of the drug was obtained at 2.66 min, on a Thermo C 18 column (4.6 mm i.d × 250 mm) utilizing Acetonitrile: 0.02 M KH2PO4 solution in the ratio 72:28 v/v as mobile phase. The flow rate was 1.1 mL/ min with UV detection at 250.0 nm. The methods are validated for specificity, precision, accuracy and robustness. Method –II is a simple, precise and economical first order derivative method for the estimation of ropinirole hydrochloride from its formulation. Ropinirole hydrochloride shows absorption maxima at 249.0 nm and in the first order derivative spectra, zero crossing at 249.0 nm was obtained with a sharp peak at 238.0 nm when n=1. Results of the analysis were validated statistically and were found to be satisfactory.


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