Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Validated RP-HPLC Method for Estimation of Aceclofenac, Paracetamol and Chlorzoxazone in Dosage Form

Author(s): G. Rathinavel, R. Priyadarsini, D. Thakur, D. C. Premanand, J. Valarmathy, S. Hemalatha, L. Samueljoshua, K. L Senthilkumar

A simple, reproducible and efficient reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for estimation of Aceclofenac, Paracetamol and Chlorzoxzone in its tablet dosage forms. Separation was done by using mobile phase consists of pH 2.8 buffer solution. The mobile phase was a 85:15 (v/v) mixture of methanol and phosphate buffer solution (ph 0.04±0.05, adjusted by addition of glacial acetic acid ) the flow rate was 1.5ml min-1 and the analyte was monitored at 232 nm. The slope, intercept and correlation coefficient were found to be 0.998 for paracetamol, 0.999 for chlorzoxazone and 0.997 for aceclofenac respectively. The percentage recovery was found to be 99.76% for paracetamol, 99.99% for chlorzoxazone and 99.56% for aceclofenac respectively. Proposed methods were found to be simple, accurate, precise, and rapid and could be used for routine analysis. This condition is applied for tablet dosage form. The statistical parameters and recovery studies were carried out and reported.


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