Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Validated RP-HPLC Method for the Estimation of Esomeprazole Enteric Coated Tablets
Author(s): Alex D Chacko, Vembu P, Dhanalakshmi KA simple, efficient and reproducible RP-HPLC method for determination of Esomeprazole in enteric coated tablet pharmaceutical dosage has been developed. The Separation was carried out on Zorbax SB C18 column (250 × 4.6 mm, 5 μm) column using buffer 6.8 g of potassium dihydrogen orthophosphate and 0.9 g of sodium hydroxide (NaOH) in 1000 ml of water (adjusted to pH 6.8 with 0.2 M NaOH). Buffer: Acetonitrile in the ratio of 40:60 v/v as diluent. The flow rate was 1.0 ml/min and effluent was detected at 280 nm. The retention times of esomeprazole was 3.2 min and the linearity ranges were found to be 50-150 μg/ml (r2=0.9990). The percentage relative standard deviation for accuracy and precision was found to be less than 2%. Hence, the method was effectively used for the regular analysis of esomeprazole in enteric coated tablet dosage form.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
