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Validated spectrophotometric method for quantitative determination of Artemether in pharmaceutical formulation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Validated spectrophotometric method for quantitative determination of Artemether in pharmaceutical formulation

Author(s): Pratap Y. Pawar*, Manisha P. Chavan, Geetanjali K. Ghanwat, Manish A. Raskar, Harshada P. Bhosale

The simple, accurate and precise UV-Spectrophotometric method has been developed and validated for quantitative determination of artemether in capsules. The method employed lN HCl as a solvent and used to derivatize a drug. The proposed method obeyed the Beer’s law in the concentration range of 5-40 μg/ml. The linear regression showed good linear relationship with r2 = 0.998, slope and intercept were 0.0182 and 0.006622 respectively. Method was validated statistically where SD and RSD were found to be satisfactorily low. Percentage recovery of the drug for the proposed method was found in the range of 99.5-100.86% indicating no interference of the capsule excipients. The results of the capsule analysis were validated with respect to accuracy, precision and recovery studies which were found to be satisfactory. LOD and LOQ for artemether were found to be 2.30 μg/ml and 4.08 μg/ml respectively. The utility of the developed method has been demonstrated by analysis of commercial formulation containing this drug.


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