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Validated spectrophotometric methods for quantitative determination of Atorvastatin calcium and Metoprolol succinate in Capsules | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Validated spectrophotometric methods for quantitative determination of Atorvastatin calcium and Metoprolol succinate in Capsules

Author(s): Sagar B. Wankhede, Nitin R. Dixit, Sohan S. Chitlange

Three simple, accurate and precise UV-Spectrophotometric methods has been developed and validated for quantitative determination of Atorvastatin calcium (ATS) and Metoprolol succinate (MET) in capsules. First method is based on simultaneous equations and the wavelengths selected for analysis were 246.5 nm (λmax of Atorvastatin calcium) and 276.5 nm (λmax of Metoprolol succinate). Second method involves multicomponent mode of analysis and the wavelengths selected for analysis were same as used in first method. Third method is based on area under curve and the wavelength ranges selected for analysis were 251.5-241.5 nm for Atorvastatin calcium and 281.5-271.5 nm for Metoprolol succinate. Linearity was obtained in the concentration range of 4-24 μg/ml and 10-60 μg/ml for Atorvastatin calcium and Metoprolol succinate, respectively. The results of analysis have been validated statistically and by recovery studies. The utility of the developed methods has been demonstrated by analysis of commercial formulation containing these drugs.


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