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Validated TLC Densitometric method for the quantification of Torsemide and Spironolactone in bulk drug and in tablet dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Validated TLC Densitometric method for the quantification of Torsemide and Spironolactone in bulk drug and in tablet dosage form

Author(s): M. C. Sharma, Smita Sharma, D. V. Kohli, A. D. Sharma

Validated high performance thin liquid chromatographic (HPTLC) method for estimation of Torsemide (TOR) and Spironolactone (SPI) in tablet dosage form. A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the determination of Torsemide and Spironolactone in dosage form. The stationary phase used was precoated silica gel 50 F254. The mobile phase used was a mixture of ethyl acetate: acetone: acetic acid (10.5: 4: 1.5v/v/v). The detection of spot was carried out at 269.0 nm. Developed method was validated in terms of linearity, accuracy, precision, repeatability and specificity. Limit of detection and limit of quantification of Torsemide and Spironolactone were found to be 120 ng/spot and 178 ng/spot, respectively. The linearity range for Torsemide and Spironolactone was found to be 360-850 ng/spot with correlation coefficient of 0.998.The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of methods.


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