Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Validated visible spectrophotometric methods for determination of Zileuton in pharmaceutical formulation

Author(s): K. Vara Prasada Rao, M. Tanuja, Y. Srinivasa Rao and T. Hemant Kumar

The present study describes two simple and selective spectrophotometric methods for the determination of zileuton in bulk and tablet formulation. Two methods were based on the oxidation of zileuton with ferric chloride followed by complex formation with 1, 10-Phenanthroline (Method A) and 2, 2’-Bipyridine (Method B). The resulting red colored chromogens are measured at 510 nm and 523 nm in the concentration ranges of 5-30 μg/ml and 5-30 μg/ml for method A and method B respectively. The proposed methods were applied successfully to determine zileuton in tablet form without interference from excipients present in pharmaceutical formulation. The results of analysis have been validated statistically and by recovery methods.


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