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Validation of RP-HPLC method for the quantification of NBromosuccinimide in Angiotensin II receptor antagonists in Pharmaceuticals | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Validation of RP-HPLC method for the quantification of NBromosuccinimide in Angiotensin II receptor antagonists in Pharmaceuticals

Author(s): T.Kaleemullah*, Mansur Ahmed and Hemant Kumar Sharma

The present paper describes the development of a reversed-phase high performance liquid chromatographic (RP-HPLC) method for N-Bromosuccinimide (NBS) determination in group of “sartans” pharmaceuticals. The gradient LC method employs solution A and solution B as mobile phase. The solution A contains 0.01%v/v Ortho-phosphoric buffer and Acetonitrile as Solution B. Successful chromatographic separation were achieved on a Zorbax XDB C18, 250mm x 4.6mm, 5μm particle size column without co-elution of drugs and its process related impurities and degradation products. The developed RP-HPLC method was validated with respect to specificity, linearity, accuracy, precision and sensitivity with detection limits and quantification limits are 0.007 mg/ml and 0.022 mg/ml respectively [1]. To the best of our knowledge, a rapid LC method for the determination of NBS in pharmaceuticals, disclosed in this investigation was not published elsewhere.


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