The present paper describes the development of a reversed-phase high performance liquid chromatographic (RP-HPLC) method for N-Bromosuccinimide (NBS) determination in group of “sartans” pharmaceuticals. The gradient LC method employs solution A and solution B as mobile phase. The solution A contains 0.01%v/v Ortho-phosphoric buffer and Acetonitrile as Solution B. Successful chromatographic separation were achieved on a Zorbax XDB C18, 250mm x 4.6mm, 5μm particle size column without co-elution of drugs and its process related impurities and degradation products. The developed RP-HPLC method was validated with respect to specificity, linearity, accuracy, precision and sensitivity with detection limits and quantification limits are 0.007 mg/ml and 0.022 mg/ml respectively . To the best of our knowledge, a rapid LC method for the determination of NBS in pharmaceuticals, disclosed in this investigation was not published elsewhere.