Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Voltammetric-oxidation and Determination of 5-Flurouracil and its Analysis in Pharmaceuticals and Biological Fluids at Glassy Carbon Electrode Mediated by surfactant cetyltrimethyl ammonium bromide

Author(s): Sanjeevaraddi.R.Sataraddi, and Sharanappa T. Nandibewoor

The voltammetric oxidation and determination of 5-Fluorouracil 5-(FU) was studied at a glassy carbon electrode (GCE) in the presence of cetyltrimethyl ammonium bromide (CTAB) by cyclic and differential pulse voltammetry at pH-7. The results indicated that the voltammetric responses of 5-Flurouracil are drastically increased in the low concentration of CTAB, suggesting that CTAB exhibits observable enhancement effect to the determination of 5- Flurouracil. Under the optimal conditions the peak current was proportional to 5-Flurouracil concentration in the range of 2.0 x 10-8 to 6.0 x 10-7 M with detection limit of 20.13nM by differential pulse voltammetry. The proposed method was applied to the determination of 5- Fluorouracil in pharmaceuticals. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.


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