Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Zinc-Mediated Entry to Functionalized 3-Substituted 3-Hydroxyindolin-2-Ones via a Modified Henry Reaction of Isatins with Bromonitroalkanes in Aqueous Media

Author(s): Rajitha Galla, Sasikala Maadwar

The reaction of 2,3-indolinediones (isatins) with stabilized organometallic reagents were investigated in aqueous media. The reaction between isatins and a variety of stabilized α-bromonitroalkanes undergo modified Henry reaction conditions to construct the 3-substituted 3- hydroxyindolin-2-ones in the presence of Zinc metal, THF: H2O (9: 1) as solvent and ammonium chloride as an additive.

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