Spectrophotometric simultaneous determination of domperidone and pantoprazol in pharmaceutical preparations

Abstract

Two simple, rapid, precise and accurate spectrophotometric methods have been developed for determination of Domperidone and Pantaprazole by simultaneous equation method and Absorbance ratio method in combined dosage form. The simultaneous equation method is based on measurement of absorbance at 284 nm and 292 nm as two wavelengths selected for quantification of Domperidone and Pantaprazole. The second method is Absorbance ratio method based on the measurement of absorbance at isoabsorptive point at 216nm and 284nm as second wavelength selected as for quantification. Both methods obeyed Beer’s law in the concentration range of 5-30 μg/ml for Domperidone and 10-60 μg/ml for Pantaprazole.The proposed methods were validated and can be used for analysis of combined dosage tablet formulation containing Domperidone and Pantaprazole