Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


2,2'-{1,2-Ethanediylbis[nitrilo(E)methylylidene]}diphenol Nickel(II) Complex: Optimization, Synthesis, Characterization, Antimicrobial, Thermal and Thermodynamic Stability

Author(s): IKenna NF, Sunday NF, Wilberforce O

There has been increased resistance of antimicrobial drugs to common bacterial ailments thereby making the treatment of such ailments laborious, time consuming and unnecessarily costly. In this study the suitability of 2,2'-{1,2-Ethanediylbis[nitrilo(E)methylylidene]}diphenol nickel(II) metal complex was examined as a potential antimicrobial agent. Solvent extraction method combined with response surface methodology modeling approach was applied in preparing the Ni(II) complex. The ligand and the prepared complex were characterized using UV-Visible, Fourier Transform Infra-Red (FTIR), magnetic susceptibility, Differential Scanning Calorimetry (DSC), Gas Chromatography-Mas Spectroscopy (GC-MS), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 Nuclear Magnetic Resonance (13C-NMR). The spectra data revealed that the orange coloured complex is diamagnetic, square planar and of 1:1 stoichiometry. Box-Behnken design a response surface methodology approach based on five factors three variables revealed that there is no significant difference between the experimental and predicted result at 95% confidence limit. In vitro antimicrobial activity of 2,2'-{1,2Ethanediylbis[nitrilo(E)methylylidene]}diphenol (H2EBNMD) and the complex was evaluated and based on the result, Ni(II)- H2EBNMD in HCl and Ni(II)-H2EBNMD in HNO3 has higher activity indices of 90.90 and 72.72% respectively at concentration of 10-3 M. Solution chemistry of complex formation indicated that the process is spontaneously feasible, endothermic, involved solvation process, follows pseudo-second order kinetic model and obeys Langmuir (R2=0.9637) and Freundlich (R2=0.9995) kinetic models. Based on the results, a novel synthetic protocol of important industrial design for the complex Ni(II)-H2EBNMD has been developed and the complex been biochemically active is recommended for the treatment of infections due to common clinically important micro-organisms such as Klebsiella sp., Escherichia coli, Pseudomonas sp. and Staphylococcus aureus.

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