Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

A Convenient Synthesis of Trisubstituted 1,3,5-triazine Derivatives and their Antimicrobial Screening

Author(s): Archana Y Cholera, Kartik D Ladva

A series of novel 1,3,5-triazine derivatives bearing various aryl amine, 2-amino pyrazine and 4-hydroxy coumarin moieties as substituents have been synthesized by an easy and conventional method using sequential nucleophilic substitution of chlorine atoms of cyanuric chloride. The reaction of cyanuric chloride with 4-hydroxy coumarin in acetone using alkaline medium at 0-5°C was afforded compound 3 in good yield. Followed by reaction 3 with 2-amino pyrazine and then various aromatic amines have afforded target compounds 6a-n in good yields. All the newly synthesized compounds were characterized by using spectroscopic analysis and then examined for their ability to inhibit the two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and one fungal species (Aspergillus niger) for biological interest.


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