Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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A Novel One Pot Facile Synthesis of 1,2,4-Triazolo-1,3,4-Thiadiazepino Fused Coumarins and Their Antimicrobial and Antituberculosis Activity Studies

Author(s): Dharati S Patel, Nilesh J Patel, Parin V Shaikh, DI Brahmbhatt

A novel series of [1,2,4]triazolo[3’,4’:2,3][1,3,4]thiadiazepino[7,6-b]coumarins (3a-l) was synthesized by the reaction of appropriate 4-chloro 3-formyl coumarins (1a-c) with various 4-amino-5-substituted-3-mercapto-1,2,4-triazoles (2a-d) in ethanol in the presence of a catalytic amount of K2CO3 under refluxing conditions. The structures of the synthesized compounds were established by elemental analysis and spectral data like IR, 1H-NMR, 13C-APT and mass analysis. The synthesized compounds were screened for their antimicrobial and antituberculosis activity. Among all the synthesized compounds, the compounds 3a, 3e, 3j and 3k were found to be more active against tested pathogens.


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