Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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A Review on Antibacterial Activity of Some Isoindole Derivatives

Author(s): Ferenc Csende, Andrea Porkoláb

Compounds which are having an isoindole moiety are important classes of the bioactive molecules. Several isoindoles and their fused derivatives were synthesized and evaluated for their efficiency as antimicrobial agents in the past years. However, several novel problems appeared with the treatment of various infections (resistant bacterial or nosocomial infections, multidrug-resistant bacterial, rare and aggressive infections), thus medicinal or pharmaceutical chemists are challenged to discover and find improved novel and more efficient drugs. The aim of this overview is to summarize the most efficient and promising isoindole derivatives to promote these developments of potent and safe drugs with fewer side effects.

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