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A Revision of the Biginelli Reaction: A Combined Experimental and Pharmacological Investigation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

A Revision of the Biginelli Reaction: A Combined Experimental and Pharmacological Investigation

Author(s): Shweta S Jadhav, Kavita T Daware, Kshitij S Varma, Khushbhu Patil, Shital J Patil, Ganesh U Chaturbhuj and Tushar N Lokhande*

Multicomponent reactions, characterized as synthetic procedures that connect three or more substrates in a highly regio and stereo-selective way to deliver structurally complex organic molecules, have seen a tremendous growth in use in the field in organic synthesis. We highlighted the recent advancements in the the synthesis of 3,4-dihydropyrimidin-2(1H)-ones which is a multicomponent Biginelli reaction. Several important Biginelli reactions and advances are also reported.


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