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Multicomponent reactions, characterized as synthetic procedures that connect three or more substrates in a highly regio and stereo-selective way to deliver structurally complex organic molecules, have seen a tremendous growth in use in the field in organic synthesis. We highlighted the recent advancements in the the synthesis of 3,4-dihydropyrimidin-2(1H)-ones which is a multicomponent Biginelli reaction. Several important Biginelli reactions and advances are also reported.