Most of the plant species of the genus Artocarpus have polyphenolic compounds. A native plant species of the said genus is Artocarpus odoratissimus Blanco. There is less scientific evidence about its medicinal properties. This study determined the preliminary toxicity and hypoglycemic property of the dichloromethane semi-crude fruit extract of Artocarpus odoratissimus. The semi-crude extract sample was obtained through fractionation of the ethanolic extract. The acute oral toxicity testing was done through OECD guidelines for the main 425 test, and Sprague Dawley rat model was used in the in vivo hypoglycemic bioassay. It was found out that the extracted sample was non-toxic up to 2000 mg/kg BW of test animals. Doses of 250 mg/kg, 500 mg/kg, and 2000 mg/kg showed a time-dependent lowering of mean blood glucose levels of the test animals after 21 days of treatment period. The 250 mg/kg and 500 mg/kg doses showed minimal glucose-lowering activity. The high dose of the extract has comparable hypoglycemic activity with the positive control, Acarbose (10 mg/kg BW). Thus, the extract sample possess hypoglycemic activity through rodent animal models.