GET THE APP

Acute Oral Toxicity and Hypoglycemic Activity of Artocarpus odoratissimusBlanco (Moraceae) fruit extract | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Acute Oral Toxicity and Hypoglycemic Activity of Artocarpus odoratissimusBlanco (Moraceae) fruit extract

Author(s): Querequincia Joseph Mari B*, Tongol Kay Ann J and Vasquez Ross D

Most of the plant species of the genus Artocarpus have polyphenolic compounds. A native plant species of the said genus is Artocarpus odoratissimus Blanco. There is less scientific evidence about its medicinal properties. This study determined the preliminary toxicity and hypoglycemic property of the dichloromethane semi-crude fruit extract of Artocarpus odoratissimus. The semi-crude extract sample was obtained through fractionation of the ethanolic extract. The acute oral toxicity testing was done through OECD guidelines for the main 425 test, and Sprague Dawley rat model was used in the in vivo hypoglycemic bioassay. It was found out that the extracted sample was non-toxic up to 2000 mg/kg BW of test animals. Doses of 250 mg/kg, 500 mg/kg, and 2000 mg/kg showed a time-dependent lowering of mean blood glucose levels of the test animals after 21 days of treatment period. The 250 mg/kg and 500 mg/kg doses showed minimal glucose-lowering activity. The high dose of the extract has comparable hypoglycemic activity with the positive control, Acarbose (10 mg/kg BW). Thus, the extract sample possess hypoglycemic activity through rodent animal models.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry