Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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An Efficient Base Catalyzed Three Component One Pot Synthesis of Novel 2-Chloro/Marcapto-Quinoline Derivatives: A Potent Antimicrobial Agent

Author(s): Devappa S Lamani, Venugopala Reddy KR, Bhojya Naik HS

The present paper describes the simple and efficient protocol for the synthesis of 2-Chloro/Marcapto-quinolin fused-1,6-Dihydropyridine Derivatives (2a-d/3a-d) by (Et3N) and (NaOEt) catalyzed three-component one pot reaction of amine, aldehyde and ketones. The newly synthesized compounds were systematically characterized by Fourier-Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR), elemental analysis, and mass spectral analysis. The antibacterial potency of these compounds was tested against Gram-positive and Gram-negative bacteria. The sulfur containing quinoline compound 3a showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Streptococcus pyogenes in consistent to halogen containing quinoline compound 2a.

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