Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

An Efficient Base Catalyzed Three Component One Pot Synthesis of Novel 2-Chloro/Marcapto-Quinoline Derivatives: A Potent Antimicrobial Agent

Author(s): Devappa S Lamani, Venugopala Reddy KR, Bhojya Naik HS

The present paper describes the simple and efficient protocol for the synthesis of 2-Chloro/Marcapto-quinolin fused-1,6-Dihydropyridine Derivatives (2a-d/3a-d) by (Et3N) and (NaOEt) catalyzed three-component one pot reaction of amine, aldehyde and ketones. The newly synthesized compounds were systematically characterized by Fourier-Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR), elemental analysis, and mass spectral analysis. The antibacterial potency of these compounds was tested against Gram-positive and Gram-negative bacteria. The sulfur containing quinoline compound 3a showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Streptococcus pyogenes in consistent to halogen containing quinoline compound 2a.


Full-Text PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan