GET THE APP

An Improved Process for the Preparation of Dabigatran Etexilate Mesylate and Synthesis of its Impurities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

An Improved Process for the Preparation of Dabigatran Etexilate Mesylate and Synthesis of its Impurities

Author(s): Sitaramaiah Devarasetty, Ravi Janni, Rambabu Nunna, Raghu Ram Suraparaju

The present invention describes the improved process for the preparation of dabigatran etexilate mesylate and impurities synthesis. The Synthesis involves easily available commercial raw materials with Acylation from n-hexyl chloroformate makes to get desired Dabigatran Etexilate from the methane sulfonic acid it is finally as a dabigatran etexilate mesylate salt with an effective yield. Catalyst free and pressure handled reactions are not performed. Dabigatran is an effective oral prodrug of the thrombin (Factor IIa) inhibitor it has been approved by FDA and is widely used to reduce the risk of stroke in patients with non-valvular atrial fibrillation.

Graphical Abstract

image


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry