Anti Covid Drug Nanoparticles in the Formulation Controlled Release Dosage Form

Sribhadram Abhishek

Abstract

Anti Covid Drug Nanoparticles in the Formulation Controlled Release Dosage Form

Author(s): Sribhadram Abhishek*

Favipiravir belongs to Biopharmaceutics Classification System Class I drug that has higher solubility and higher permeability. The drug needs to be administered frequently (2-3 times a day) total 1800 mg drug /day and also have shorter half-life it means the drug is eliminating from the body in 2-4.5 hrs. The present study was to overcome the half-life of favipiravir. So, it is formulated into nano-particles were prepared using a hydrophobic polymer-ethyl cellulose by modified solvent evaporation technique. Optimized formulation was selected and prepared into a tablet formulations using different excipients which control the drug release. The favipiravir loaded nanoparticles were sent to (FT-IR) studies and it shown the absence of interactions of drug with other excipients and also other studies like DSC, SEM. At the end of the 10th hour, F1-F6 formulations released 84.71%-96.43% of the drug. Among all the formulations F6 was chosen as a best formulation and used to prepare a various controlled release tablets. Based on many evaluation studies, the best tablet formulation was chosen.

The in vitro dissolution drug release of drug was controlled over extended period of time which was affected by the polymer and its amount of polymer.

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