In the present research, application of central composite design (CCD) was used for optimization of Cr (VI) removal from aqueous solution using Boodlea struveiodes, green marine algae as an adsorbent material. Batch biosorption experiments were conducted according to CCD which is a subset of response surface methodology. The influence of various process parameters such as contact time, pH and biomass dosage on the removal process was investigated. Furthermore, it is essential to understand the effect of process parameters to define the best possible conditions for adsorption, therefore, these factors were considered and a total of 16 trials were run according to the CCD. From the Analysis Of Variance (ANOVA) table and R2 value (0.9707), quadratic model was predicted to be significant with the best fit to the experimental data.