Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Biochemical and Immunomorphometric Comparative Study Using Neem and Propolis Extracts For Hepatorenal Protection in Rats

Author(s): Yassen NN, El-Sayed ME, Hazaa MM, El-Dougdoug KA, Othman, M, Elwan EE

Background: Exposure to Alternariol or Patulin toxin is known to have toxic effects in different animal species, and to express toxicity in cells.

Purpose: The aim of this study is to compare the protective effect of Neem and Propolis extracts in hepatorenal toxicity caused by some mycotoxins.

Study design: Animals were divided into seven groups each of 5 animals and received single oral dose of 3 ml/rat, group 1, received A. alternata toxin; group 2, Alternaria alternate plus neem extract; group 3, A. alternata plus propolis extract; group 4, received Penicillium expansum toxin; group 5, P. expansum Patulin extract plus neem extract; group 6 P. expansum Patulin extract plus propolis extract; group 7, received normal water as a control.

Methods: ALT, Urea and Creatinine were detected in all groups after two weeks of feeding, the expression of Caspase-3 and iNOS in liver and kidney tissues were assessed immunomorphometrically by image analysis system.

Results: Animals received Alternariol or Patulin toxin alone showed significant changes in serum biochemical parameters and histological picture of the liver and kidney. Whereas, animals treated with Neem or Propolis extract in combination with Alternariol or Patulin toxins were comparable to control. The immunomorphometric parameter detected that the Propolis extract is more effective in the treatment especially with P. expansum toxin.

Conclusion: It could be concluded that the extract of Neem or Propolis induce its protective effect via increase the antioxidant capacity and the inhibition of lipid peroxidation.


Full-Text PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş