GET THE APP

Cardiac Glycoside Poisoning: Pharmacological Therapy | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Cardiac Glycoside Poisoning: Pharmacological Therapy

Author(s): Hari Prasad Sonwani*, Pragya Sahu and Rashi Bandey

Because cardiac glycosides are found in natural sources and are widely used in therapeutic settings, they are a significant cause of poisoning. Toxicological manifestations of poisoning can range in intensity. Bradycardia, heart bloc and gastrointestinal symptoms are the main clinical characteristics. Ventricular fibrillation or tachycardia causes death. Numerous treatments have been employed; the most popular ones include activated charcoal, atropine, β-adrenoceptor agonists, magnesium, anti-digoxin Fab and temporary pacing. More unusual treatments include fructose-1,6-diphosphate (which is undergoing a clinical trial) and anticalin. Even with therapies that have been around for decades, there is still disagreement over the best way to use them, when to use them and what dosage would produce the best results. This adds to the variation in use that exists worldwide. Access is another aspect that affects utilization. Accessibility obstacles include the need for financial resources (such as anti-digoxin Fab in resource poor nations) or transfer to a specialized center (for example, to obtain temporary pacing). According to recent findings, people with chronic digoxin poisoning may not benefit much from anti-digoxin Fab and the current methods for determining the dose in cases of digoxin toxicity may be oversimplifying the necessary dosage. More affordable and potent medications are needed, especially to treat yellow oleander toxicity, which is a major issue in nations with limited resources.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry