In very recent days multivariate calibration techniques are used to resolve mixtures of double or triple compounds with similar spectral characteristics. In many cases, these multivariate methods for the study of spectral data have many more benefits like simple processing and cheaper analysis. These methods have been very often applied for quantitation of drugs, as HPLC methods are tedious and conventional spectroscopic methods were slow, expensive and complex. The work proposal describes new spectrophotometric methods for the concurrent estimation of Perindopril (PRN) and Losartan (LRN) in their mixtures and dosage form. The stated chemometric methods are multivariate techniques including PCR and PLS. These techniques employ the concentration statistics matrix, produced by using the several combinations containing the two drugs dissolved in methanol. The absorbance input matrix related to the concentration was deduced by studying the absorbance in between 200–350 nm at 1 nm intervals on the zero-order spectra which does not require any extraction steps. The accuracy values, precision, and linearity ranges of the methods have been tested, and analysing the combinations having the studied drugs has then been validated. The results confirmed the suitability of the recommended method for the accurate and highly precise analysis of Perindopril and Losartan in pharmaceutical preparations. These developed methods were applied exactly to the formulation mixture preparations without earlier treatment. Also, no expensive laboratory procedure is required. Moreover, the determined techniques are suitable for study without any of the excipient interference.
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