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Comparision of Anti-diabetic Activity of Plant Based and Synthetic Aryltetalin Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Comparision of Anti-diabetic Activity of Plant Based and Synthetic Aryltetalin Derivatives

Author(s): Chaitramallu M*, Parvathi G R, Sindhu GM and Ranjini P

The aryltetralin compound podophyllotoxin was extracted from the roots of plant P. peltatum and analogues of aryltetralin were synthesized using tetralone as a starting material. They were synthesized by replacing 1, 3‐methylene dioxy ring with dimethoxy, hydroxy, methyl, chlorine and hydrogen and methoxy group. The structure of the final compounds was confirmed by 1H NMR, 13C NMR, mass spectra and elemental analysis data and the analogues were screened for anti-diabetic activity. It is noteworthy that, all the synthesized derivatives exhibits good anti-diabetic activity with respect to standard reference.


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