The wound closure has been a matter of concern for the patients more than the surgery itself. Major reasons include the endless pain and the complications involved in the conventional tissue adhesion methods like sutures, staples, screws, etc. Not only the pain involved in suturing and in removing sutures post healing but also the infections in the sutured wounds along with the cosmetically unacceptable scars are the major reasons for the development of the tissue adhesives and sealants for the wound closure. Tissue adhesives seem to be of great importance since they have the capability of either completely replacing the conventional wound closure technique or at the minimal provide a support for reducing the number of stitches. The ideal dressing should achieve rapid healing at reasonable cost, with minimal inconvenience to the patient. This article offers a review of the emerging technology using cyanoacrylates for achieving improved, painless and patient compliant wound healing. Cyanoacrylates are strong, fast-setting liquid monomers. These upon exposure to moisture start to set due to polymerization reaction. Fast-setting, high tensile strength, good flexibility, durability, waterproof nature and transparent appearance, are few of the properties which make cyanoacrylates ideal for wound closure and skin barrier products. General formation and formulation approach of cyanoacrylates towards achieving optimum physical properties, mechanism of tissue adhesion and evaluation parameters along with applications, safety assessment, their key advantages and shortcomings are also considered briefly.