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Design, practical synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives incorporated with quinolone moiety as microbial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design, practical synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives incorporated with quinolone moiety as microbial agents

Author(s): Peddakotla Venkata Ramana, Dasampalli Nese Satyanarayana, Karnatakam Doraswamy and Laxmanarao Krishnarao Ravindranath

A series of novel 1,3,4-oxadiazole derivatives incorporated with quinolone moiety were designed and synthesized as biological compounds. In vitro antibacterial activity of the synthesized compounds (5a-g) was performed against Gram +ve microorganisms Staphylococcus aureus (MTCC No. 96), Pseudomonas aeruginosa (MTCC No. 1688), Bacillus subtillis (MTCC No. 121) and Gram -ve microorganisms Escherichia coli (MTCC No. 521). In vitro antifungal activity of compounds was screened against Candida albicans. The structure of all new compounds was confirmed by IR, 1H-NMR and Mass spectra.


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