Eco-friendly Synthesis of andalpha; -Aminonitriles Catalysed by Epzg | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Eco-friendly Synthesis of α -Aminonitriles Catalysed by Epzg

Author(s): Rahul Patil*, Ankush Mali, Shivaji Burungale, Uday Lad, Sanjay Jadhav and Uttam More

A simple, proficient and ecofriendly procedure has been developed for the three component coupling of aromatic aldehyde, substituted amines and trimethylsilyl cyanide produce α-amino nitriles. The α-amino nitriles are synthesized in high yields (90-91%) in a few minutes (18-45 min) under solvent-free conditions using EPZG catalyst at room temperature.

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