In recent years, medical image registration has gained considerable attention to gather as much information as possible for the diagnosis of the disease. The purpose of this study was to apply positron emission tomographic (PET) detector technology for simultaneous PET imaging of the human brain and skull base. Following phantom studies, five patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET imaging. We simulated spheroid geometry with a radius of (199 mm), patient bore with of radius of (185 mm), which is compatible with brain size. Positron emission tomography with 2- fluorine-18] fluoro-2-deoxy-d-glucose allows detection of neurodegenerative disorders earlier than is otherwise possible. PET data enabled accurate registration of morphologic and multifunctional information. Simultaneous PET imaging is feasible in humans; opening up new possibilities for the emerging field of molecular imaging. The evaluation study indicates that the spheroid geometry delivers better axial resolution whereas.
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