Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Identification of Impurities and Improved the Synthesis of Lacosamide

Author(s): Srinivasachary K, Subbareddy D, Shankar BR, Narayan GKSS, Shashikant T, Somannavar YS,Ramadevi B

The three step process used in the synthesis of Lacosamide (1) was studied and optimized leading to a more robust process. The key process improvements identified and included implementation of telescopic process improvements identified and incuded extraction and solvent exchange and significant optimization of final reaction including the beneficial effect of using aqueous ammonia resulting zero ppm level of residual reagent of dimethyl sulfate.

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