Larvicidal and ovicidal activities of some cinnamaldehyde derivatives Against Anopheles gambiae, malaria vector agent | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Larvicidal and ovicidal activities of some cinnamaldehyde derivatives Against Anopheles gambiae, malaria vector agent

Author(s): Victor N’goka, Guy Crépin Enoua, Tony Wheellyam Pouambeka, Ghislain Kende, Gelase Fredy Nsonde Ntandou, Ninon G.E.R. Etsatsala* and Ouamba Jean-Maurille

This study presents the research studies conducted on vector control for the fight against malaria, a very devastating disease with a high rate of mortality and morbidity in sub-Saharan Africa. Following an ethnobotanical, ethnopharmacological, chemical analysis, larvicidal and ovicidal activities of essential oils as well as their main chemical constituents; eleven compounds including related derivatives have been either purchased or synthesized and evaluated for their larvicidal and ovicidal activities. Cinnamaldehyde and o-Nitrocinnamaldehyde exhibited the highest activity withLC50 = 55 mg /L following by Citral (LC50 = 64 mg /L), Cinnamic acid (LC50 = 65 mg /L), and Thymol (L50 = 67 mg /L), against larvaes. Furthermore, Citral, and Cinnamaldhyde showed the highest activity against eegs, with LC50 = 0,015 and 0.020 respectively. This study revealed that the compounds were more active than their corresponding essential oils. Finally, this research study also showed that it would be important to carry out a more in-depth study of the structure activity relationship on chemical constituents or derivatives of essential oils, to improve the activities.

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