Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Macrocyclic Schiff Base Complexes-Preparation, Characterisation and Biological Activity

Author(s): Vanita Goel, Sonika, Rajesh Malhotra

New macrocyclic Schiff base complexes of Transit. Metals was synthesized using 1, 3-Dibenzoylbenzene and 1, 2-Diaminoethane/1,2- Diaminobenzene. The complexes MLX2 [where M=Zn(II), Co(II), Cu(II) and Ni(II); L was a condensation product of 1, 3-Dibenzoylbenzene and 1, 2-Diaminoethane/1, 2-Diaminobenzene; X=Cl-, CH3COO- ] were synthesized using template method. These complexes were characterized by elemental analysis, spectral analysis (IR, NMR), Magnetic moment measurements, ESR studies and electronic measurements. All the complexes were screened for gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and phytopathogenic fungi (Candida albicans, Saccharomyces cerevisiae). Minimum inhibitory concentration of the synthesized complexes was also measured and compared with standard antibacterial Ciprofloxacin and antifungal Amphotericin-B.