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One Pot Synthesis of (4z)-4-(Benzylidene/Substituted Benzylidene)-1n-Methyl-2-(Styryl/Substituted Styryl)-1h-Imidazol-5(4h)-One Derivatives and their Anti-Bacterial Activity Evaluation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

One Pot Synthesis of (4z)-4-(Benzylidene/Substituted Benzylidene)-1n-Methyl-2-(Styryl/Substituted Styryl)-1h-Imidazol-5(4h)-One Derivatives and their Anti-Bacterial Activity Evaluation

Author(s): Anitha Rani V, Bharathi Kumari Y

One pot synthesis of (4z)-4-(benzylidene/substituted benzylidene)-1n-methyl-2-(styryl/substituted styryl)-1h-imidazol-5(4H)-one derivatives have been developed. Initially, (Z)-4-benzylidene-2-methyl-oxazol-5(4H)-one was treated with methylamine and refluxed for 5 h in ethanol to produce (Z)-2-acetamido-N-methyl-3-(phenyl/substituted phenyl) prop-2-enamides. which were made to react with the schiff bases benzylidine/substituted benzylidine anilines in the presence of Et3N as a catalyst in ethanol medium under reflux condition for 2 hr to produce in situ (4Z)-4-(benzylidene/ substituted benzylidene)-1N-methyl-2-(styryl/substituted styryl)-1H-imidazol-5(4H)-one derivatives in good yields and tested for their anti-bacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus Subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus Subtillis compared to standard drug streptomycin.


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