One pot synthesis of (4z)-4-(benzylidene/substituted benzylidene)-1n-methyl-2-(styryl/substituted styryl)-1h-imidazol-5(4H)-one derivatives have been developed. Initially, (Z)-4-benzylidene-2-methyl-oxazol-5(4H)-one was treated with methylamine and refluxed for 5 h in ethanol to produce (Z)-2-acetamido-N-methyl-3-(phenyl/substituted phenyl) prop-2-enamides. which were made to react with the schiff bases benzylidine/substituted benzylidine anilines in the presence of Et3N as a catalyst in ethanol medium under reflux condition for 2 hr to produce in situ (4Z)-4-(benzylidene/ substituted benzylidene)-1N-methyl-2-(styryl/substituted styryl)-1H-imidazol-5(4H)-one derivatives in good yields and tested for their anti-bacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus Subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus Subtillis compared to standard drug streptomycin.
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