Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Potential antibacterial agents: Phenylpyrazolines, cyanopyridines and isoxazoles

Author(s): A. N. Solankee, S. H. Solankee, G. A. Patel, K. P. Patel and R. B. Patel

A series of 2-(4'-chloro phenyl amino)-4-(4'-fluoro phenyl amino)-6-[4'-{1''-phenyl-5''- substitutedphenyl-2''-pyrazolin-3''-yl}phenylamino]-s-triazine(7a-e), 2-(4'-chlorophenylamino)-4-(4'- fluorophenylamino)-6-[4'-{2''-amino-3''-cyano-4''-substitutedphenyl-pyridin-6''-yl}phenylamino]-striazine (8a-e) and 2-(4'-chloro phenyl amino)-4-(4'-fluoro phenyl amino)-6-[4'-{5''-substituted phenyl-isoxazole-3''-yl}phenylamino]-s-triazine (9a-e) were prepared. The structures of synthesized were confirmed on the basis of spectral data. The compounds were screened for their in vitro antibacterial activity using Gram-positive and Gram-negative bacteria.


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