Preparation and characterization of novel antibacterial nano- ceramic-composites for bone grafting | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Preparation and characterization of novel antibacterial nano- ceramic-composites for bone grafting

Author(s): Hanan. H. Beherei, A. El-Magharby, M.S. Abdel-Aal

Novel nanocomposites scaffolds were prepared by impregnating nano-calcium phosphate (HA)/ walled carbon nanotube ( MWCNT)/ZnO nano-particles into the alginate polymers matrix. The nano-composite materials were characterized using X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR) analyses mechanical test and Scanning Electron Microscopy (SEM) before in- Vitro and antibacterial test. The in-vitro behavior was assessed via measurement of calcium and phosphorus ions in SBF (simulated body fluid). FT-IR and SEM of the composites were performed pre and post immersion in SBF. The results prove that the bone like apatite layer formation was enhanced on the biopolymeric composite surface more than that on the polymeric composite containing more MWCNT. Therefore, the data confirmed that MWCNT plays an important role in the enhancement of the apatite formation. The conclusions proved that the MWCNT /polymeric biocomposites, containing more of MWCNT, are promising for antibacterial and bone remodeling applications.


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