Abstract

Protein Assembly: An Understanding and Clarification

Author(s): Sivakumar B*, Eldhose M J, Asish S, Vipuldas MK, Anila Kumar and Vidhya PM

Alzheimer's disease is characterized by the accumulation of mis folded proteins that form fibrillary amyloid deposits in specific regions of the central nervous system. This leads to memory loss, changes in personality, abnormal behavior and a decline in cognitive abilities. In the early stages of the disease, individuals may experience short-term memory loss, difficulty remembering names and addresses and an inability to learn new information. As the condition progresses, these changes become more pronounce and individuals may even forget the way to their own home. AD patients often exhibit emotional features such as frustration, irritability and hostility. Genetic factors account for seventy percent of Alzheimer's cases, while environmental factors contribute to twenty-one percent. Late-onset Alzheimer's, which occurs after the age of 60, is the most common form of the disease. Currently, the most widely accepted treatment strategy for Alzheimer's involves the use of cholinesterase inhibitors, which work by inhibiting the activity of the enzyme Acetylcholinesterase (AChE) and increasing levels of acetylcholine in the brain. Examples of these inhibitors include rivastigmine, donepezil, tacrine, galantamine and memantine. However, there is currently no cure for Alzheimer's disease and available medications only help to alleviate symptoms. Herbal medicine offers an alternative approach to managing and slowing down the progression of AD.

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