Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

QSAR Analysis on 2-(4-(Piperidin-1-yl)piperidin-1-yl)-6-Substituted Thiazolo[4,5-B]Pyridines as H3 Receptor Antagonists

Author(s): Sanmati K. Jain, Lokesh Sahu, Rahul Jain, Arvind K. Yadav

Quantitative structure activity relationship (QSAR) study was performed on a series of 2-(4-(piperidin-1- yl)piperidin-1-yl)-6-substituted thiazolo[4,5-b]pyridines possessing H3 receptor antagonistic activity for establishing quantitative relationship between biological activity and their physicochemical/ structural properties. Several statistical regression expressions were obtained using partial least squares regression (PLSR) analysis. Three statistical significant models were generated [r2 = 0.8130, q2 = 0.6103, pred_r2 = 0.9818; r2 = 0.8166, q2 = 0.6213, pred_r2 = 0.9421 and r2 = 0.8164, q2 = 0.6392, pred_r2 = 0.9399 for model 1, 2 and 3 respectively] indicating that biological activity is influenced by the descriptors T_C_N_5, T_N_O_2, XKMostHydrophobicHydrophilicDistance and XAHydrophilicArea.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan