2,2,6,6-Tetramethylpiperidin-4-one reacts with 2 moles of aromatic aldehydes and thiosemicarbazide or semicarbazide hydrochloride in different conditions to afford piperidine derivatives 1a-f and pyrazolo(4,3-c)pyridine derivatives 2a-f. Pyrazolo[4,3-c]pyridine-2-carbothioamide derivative 2b reacts with benzophenone, 4-cholorobenzophenone, and 4-bromobenzophenone to give 5-(pyrazolo[4,3-c]pyridine-2-yl) thiazole derivatives 3a-c. Piperidine derivative 1b reacts with acetic anhydride to afford compounds 4a-b. Pyrazolo(4,3-c)pyridine derivative 2c reacts with acetic anhydride to afford compounds 5a-b. Hydrazinecarbothioamide derivative 1a reacts with benzoin and benzoin oxime to give compounds 6, and 7 respectively. Anticancer evaluation of some of synthesized compounds is reported.
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