Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Reactions of Triacetonamine Part II, Synthesis of Novel Pyrazolo(4,3-c)pyridine Derivatives, and 2-(Piperidin-4-ylidene)hydrazinecarbothioamide Derivatives Derived From 2,2,6,6-Tetramethyl-piperidin-4-one for In vitro Anticancer Evaluation

Author(s): Mahmoud NM Yousif, Ahmed A Fayed, Nabil M Yousif

2,2,6,6-Tetramethylpiperidin-4-one reacts with 2 moles of aromatic aldehydes and thiosemicarbazide or semicarbazide hydrochloride in different conditions to afford piperidine derivatives 1a-f and pyrazolo(4,3-c)pyridine derivatives 2a-f. Pyrazolo[4,3-c]pyridine-2-carbothioamide derivative 2b reacts with benzophenone, 4-cholorobenzophenone, and 4-bromobenzophenone to give 5-(pyrazolo[4,3-c]pyridine-2-yl) thiazole derivatives 3a-c. Piperidine derivative 1b reacts with acetic anhydride to afford compounds 4a-b. Pyrazolo(4,3-c)pyridine derivative 2c reacts with acetic anhydride to afford compounds 5a-b. Hydrazinecarbothioamide derivative 1a reacts with benzoin and benzoin oxime to give compounds 6, and 7 respectively. Anticancer evaluation of some of synthesized compounds is reported.


Full-Text PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan