Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Spectrophotometric Study Oxidation of Amlodipine Besylate by Chloramine-T in Acidic Buffer pH (4.3) Medium

Author(s): Fathyah Omar Abdulsalam, Prema Kadappa Reddy, Asha Iyengar T

Kinetic oxidation of Amlodipine besylate (AML) with Chloramin-T(CAT) has been studied in acidic buffer medium (4.3). The experimental rate of reaction was found to be -d[CAT]/dt=k [CAT]o[AML]o[OH–]–0.52 at 306 K. The stoichiometry of the reaction was found to be 1:1 and the oxidation products of AML were identified. The effect of added halide ions, reduction product (p-toluene sulphonamide, PTS), ionic strength (NaClO4) and dielectric constant of the medium was studied on the rate of reaction. The activation parameters have been deduced from Arrhenius plots and proper mechanism has been worked out.


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