Alzheimer’s Disease (AD) is a major neurodegenerative disorder affecting areas of brain related to learning and memory. AD may be presenile/senile onset of and occurrence of disease before or after the age of 60 years as well as median age of population. Based on the reported anti-AD activity profile of aryl sulphonamide analogs, the series of compounds (13a-f) were designed. The effect of synthesized substituted sulphonamide derivatives (13a-f) on Alzheimer’s dementia models was evaluated using behavioral (MWM test) and pathological studies. This series of compounds displayed good to moderate anti-AD activity and need further structure optimization.