Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and Anti-Convlsant Evaluation of Some Novel 4-Phenyl-6-Methyl-5-[(2'-Substituted-Phenyl) 1,3,4-Oxadiazole)]-3,4-Dihydropyrimidin-2(1h)-One Derivatives

Author(s): Bharat SH

The reaction of substituted aromatic aldehydes with ethylacetoacetate in presence of urea yielded 5-Ethoxy carbonyl-6- methyl-4-phenyl-3, 4- dihydropyrimidin-2 (1H)-one.(1), which on treatment with hydrazine hydrate produced 4-phenyl-6-methyl-2-pyrimidinone 5-carbohydrazide.(2), cyclization with substituted benzoic acids in presence of phosphorous oxychloride produced 4-phenyl-6-methyl-5-[(2'- substituted-phenyl) 1,3,4- oxadiazole)] - 3, 4-dihydropyrimidin-2(1H)-one. 3(a-i). Purity was checked by Thin Layer Chromatography (TLC) and the chemical structures of synthesized compounds were elucidated by their Infra-Red (IR), Proton nuclear magnetic resonance (1H-NMR) analysis data. The synthesized compounds were screened for Anti-convulsant activity.

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