Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and Anti-Tubercular Study of Some Transition Metal Complexes of Hydrazone Derivatives Derived from Benzofuran-2-Carbohydrazide

Author(s): Bhushan Nazirkar, Udaysinha Patil, Bapu Thorat, Mustapha Mandewale, Hemant Gaokar, Arjun Pandhare, Ramesh Yamgar

The benzofuran-2-carbohydrazide based new hydrazone ligands and their transition metal complexes have been prepared. These ligands and metal complexes were characterized by different spectroscopic techniques. The preliminary results of antituberculosis study showed that the hydrazones exhibited very good antituberculosis activity. Among the tested compound 3b was found to be most active with minimum inhibitory concentration of 1.6 μg/mL against Mycobacterium tuberculosis.