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Synthesis and Anti-Tubercular Study of Some Transition Metal Complexes of Hydrazone Derivatives Derived from Benzofuran-2-Carbohydrazide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and Anti-Tubercular Study of Some Transition Metal Complexes of Hydrazone Derivatives Derived from Benzofuran-2-Carbohydrazide

Author(s): Bhushan Nazirkar*, Udaysingh Patil, Bapu Thorat, Mustapha Mandewale, Hemant Gaokar, Arjun Pandhare and Ramesh Yamgar

The benzofuran-2-carbohydrazide based new hydrazone ligands and their transition metal complexes have been prepared. These ligands and metal complexes were characterized by different spectroscopic techniques. The preliminary results of antituberculosis study showed that the hydrazones exhibited very good antituberculosis activity. Among the tested compound 3b was found to be most active with minimum inhibitory concentration of 1.6 μg/mL against Mycobacterium tuberculosis.


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