A novel 2-substituted benzimidazole derivatives were synthesized by the reaction of naproxen with aromatic diamine-o-Phenylenediamine. All the compounds were characterized by InfraRed (IR), Proton Nuclear Magnetic Resonance (1H-NMR). The synthesized derivatives were screened for Anthelmintic and anti-inflammatory activities. Eicosanoids in Helminthes appear to play a dual role, for metabolism or maturation of the organism and communication with the host on a cellular basis. Production of eicosanoids correlates with both penetration and transformation, two activities required for infection. Eicosanoid is involved in control of virulence mechanisms. Therefore in the view of designing novel anthelmintic agent we have synthesized benzimidzole derivative of Naproxen. Naproxens react with free amine group to from benzimidazle derivatives. In this way three derivatives were synthesized and screened for Anthelmintic activities against Indian adult earthworms (Pheretima Posthuma) at various concentrations (5 mg/ml, 10 mg/ml and 20 mg/ml). All compounds showed their significant action for time taken to paralysis and death when compared standard.
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