GET THE APP

Synthesis and Biological Evaluation of 2-Substituted Benzimidazole Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and Biological Evaluation of 2-Substituted Benzimidazole Derivatives

Author(s): Nilam B Pawar, Deepak Yadav, Bhushan R Pawar

A novel 2-substituted benzimidazole derivatives were synthesized by the reaction of naproxen with aromatic diamine-o-Phenylenediamine. All the compounds were characterized by InfraRed (IR), Proton Nuclear Magnetic Resonance (1H-NMR). The synthesized derivatives were screened for Anthelmintic and anti-inflammatory activities. Eicosanoids in Helminthes appear to play a dual role, for metabolism or maturation of the organism and communication with the host on a cellular basis. Production of eicosanoids correlates with both penetration and transformation, two activities required for infection. Eicosanoid is involved in control of virulence mechanisms. Therefore in the view of designing novel anthelmintic agent we have synthesized benzimidzole derivative of Naproxen. Naproxens react with free amine group to from benzimidazle derivatives. In this way three derivatives were synthesized and screened for Anthelmintic activities against Indian adult earthworms (Pheretima Posthuma) at various concentrations (5 mg/ml, 10 mg/ml and 20 mg/ml). All compounds showed their significant action for time taken to paralysis and death when compared standard.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry