GET THE APP

Synthesis and Biological Evaluation of N,N�¢����-Bis(1-(2-Hydroxyphenyl)Ethylidene)-2-Methylmalonohydrazide Schiff�¢����s Base and its Metal Complexes of First Transition Series | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and Biological Evaluation of N,N�¢����-Bis(1-(2-Hydroxyphenyl)Ethylidene)-2-Methylmalonohydrazide Schiff�¢����s Base and its Metal Complexes of First Transition Series

Author(s): Saini S, Pal R, Gupta AK, Beniwal V

In search of new chemical nucleases the synthesis of methylmalonohydrazide based hydrazone Schiff base and its colored complexes with transition metal Co(II), Ni(II), Cu(II), Mn(II), and Zn(II) have been synthesized. All synthesized compounds were screened for antibacterial activity against gram (+) and gram (-) bacteria using Oxacillin and Penicillin-G as a reference standard and their DNA photocleavage potential were carried out by using the plasmid DNA via gel electrophoresis method. From experimental results it has been observed that biological activity increases significantly upon coordination. The synthesis of hydrazone Schiff’s base, N,N’-bis(1-(2-Hydroxyphenyl)ethylidene)-2-methylmalonohydrazide (MAPLH2) have been achieved by a condensation reaction between 2-methylmalonohydrzide and 1-(2-Hydroxyphenyl)ethanone. Furthermore, new transition metal complexes were formed by the reaction between novel ligand and different transition metal ions in 1:1 stoichiometric ratio. All the synthesized compounds were characterized on the basis of various spectroscopic techniques like Proton Nuclear Magnetic Resonance (1H-NMR), Ultraviolet (UV)-Visible, elemental analysis, Fourier-transform infrared (FT-IR) and mass spectroscopy. 1H-NMR data of complexes showed the coordination of hydroxy atom with subsequent loss of proton and FT-IR spectral data reveals that the participation of nitrogen atom of ligand in coordination with metal ion.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry