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Synthesis and Biological evaluation Of Some New Benzoyl Pyrazole Derivatives bearing a 6,8-Dibromo-2-methylquinazolin-4-one Moiety | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and Biological evaluation Of Some New Benzoyl Pyrazole Derivatives bearing a 6,8-Dibromo-2-methylquinazolin-4-one Moiety

Author(s): Komal Savaliya* and Pankaj S. Patel

A new series of 3-[4-(1-benzoyl-5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl)phenyl]-6,8-dibromo-2-methylquinazolin-4-one have been synthesized by the condensation reaction of 6,8-dibromo-3-{4-[5-(substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-2-methylquinazolin-4-one with benzoyl chloride by using pyridine as a solvent. The intermediate have been synthesized by refluxation of 6,8-dibromo-3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-methylquinazolin-4-one (0.01M) and 99% hydrazine hydrate (0.015M) by using ethanol (50ml) as a solvent with various aldehydes. The chemical structures of synthesized benzoyl pyrazoline derivatives were characterized by their IR, NMR and spectral data. The newly synthesized compounds were screened for their antibacterial and antifungal activities by Agar Cup method.


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