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Synthesis and Characterization of Novel Mono Carbonyl Curcumin Analogues of Pyrazole Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and Characterization of Novel Mono Carbonyl Curcumin Analogues of Pyrazole Derivatives

Author(s): Maddineni A Kumari*, Chunduri V Rao and Begari N Raju

(E)-4-aryl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-one derivatives were (4a-d) synthesized by the condensation of 3-aryl-1-phenyl-1H-pyrazole-4- carbaldehyde derivatives (3a-d) with acetone in the presence of sodium hydroxide. Compounds (4a-d) on condensation with different aldehydes give mono carbonyl curcumin analogues (MACs) of pyrazole derivatives (6a-x) in good yield.

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