GET THE APP

Synthesis and some Reactions of [4-Oxo-4-(3,4,5-Trimethoxy-Benzylidene)-4-Dihydro-Thiazole-2-Yl]-Acetonitrile with Expected Biological Activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and some Reactions of [4-Oxo-4-(3,4,5-Trimethoxy-Benzylidene)-4-Dihydro-Thiazole-2-Yl]-Acetonitrile with Expected Biological Activity

Author(s): Mahmoud NA

4-oxo-5-(3,4,5-trimethoxy-benzylidene)-4,5-dihydrothiazol-2-yl)-acetonitrile 1 was prepared and treatment with sodium azide, phenyl isothiocyanate, 5-bromosalicylaldehyde, thioacetamide and ethylacetate to give the corresponding 2-substitute-4-oxo-5-(3,4,5-Trimethoxy benzylidene-4,5-dihydrothiazole-2-yl) derivatives 2,3,5,6 and 8. Treatment of 3 and 6 with phenacylbromide gave 4 and 7a also 4-oxo-2-[4-oxo- 5-(3,4,5-trimethoxy benzylidene)-4,5-dihydro-thiazol-2-yl)-butyronitrile 8 when reacted with malononitrile, 2-cyanoacetohydrazide, hydrazine hydrate, benzaldehyde and 2-amino-2-(hydroxylmethyl) propane-1,3-diol afforded 9,13,15, 16 and 17. Treatment of compound 9 with sulfur gave 10 which in turn treated with p-nitrobenzaldehyde to give Schiff base 11, which on further treatment with thioglycollic acid gave 12. Cyclization of compound 13 with acetic acid gave 14. The newly synthesized compounds screened for their in vitro antitumor activity against human cancer cell line.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry