Synthesis and utility of naphthalene-benzofuran chalcone in different types of reactions for syntheses of various heterocyclic compounds such as pyrazole, isooxazole, thiazole, pyrimidine, pyran, pyridine rings were done. Also, formation of azide derivatives from pyridine acetohydrazide that used in synthesis of 2,4-dioxothiazolidine and 2,4-dioxo-1,2-dihydroquinazolin derivatives were run and reacted with different types of phenol and amine such as phenol, 4-aminophenol, p-chloroaniline and 4-aminopyridine respectively. The structures of the newly synthesized compounds were confirmed based on different spectroscopic and elemental analyses (IR, 1H, 13C-NMR and MS). Selected new compounds were evaluated their activity as antiviral against Hepatitis A Virus (HAV) using 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) and Tissue Culture Infectious Doses (TCID50) assays. These compounds showed high to moderate activity of antiviral activity. In addition, The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of human solid tumor cell lines (U937: Cell line human lymphoblast lung from human, MOLT-4: Human lymphoblast; Acute lymphoblastic leukemia, K562: Cell line human leukemic blood from human).
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